Nishimura Lab

Tissue Engineering and Biotechnology

Leading the scientific community

We hosted a conference: Craniomaxillofacial disorders and solutions in man and animals Nov 11-13, 2016. Arzi et al., Craniomaxillofacial Disorders and Solutions in Humans and Animals, J Dent Res, 97(4):364-370, 2018

A new tool for drug delivery

As the result of collaboration with Dr. V. John, Alzheimer Disease researcher, we developed a new drug delivery system, called “synthetic exosomes”, which can carry a wide range of small molecule drugs, antibodies, nucleic acids etc and pass through epithelial and endothelial layers. We are currently testing its validity for trans-dermal, trans-oral mucosa and trans-BBB drug delivery. Subbiah et al, Deformable nano vesicles synthesized through an adaptable microfluidic platform for enhanced localized transdermal drug delivery, J Drug Deliv, 2017:4759839, 2017

We ease your pain

We discovered the previously unknown 3’UTR sequence of voltage gated sodium channel 1.8 (NaV1.8), which was found to play a key role in chronic neuropathic pain. The newly discovered 3’UTR of NaV1.8 is considered as a novel therapeutic target with minimal side effect of pain control. Hirai et al., Aberrant plasticity of peripheral sensory axons in a painful neuropathy, Sci Rep, 7(1):3407, 2017.